Building Bone from Scratch.

Small molecule technologies.

Transforming musculoskeletal care.

Helping the body’s own bone building machinery do its job.

These are the technologies behind SkelRegen


 Small Molecule Technology

Small molecules are the logical and cost-effective game-changing solution for skeletal tissue regeneration.  SkelRegen has several families of small molecules being developed for all segments of musculoskeletal tissue regeneration.  Many of them already have FDA clearance for alternative uses and thus have acceptable known safety and toxicity profiles.

 Spine Fusion & Large Segmental Defects

Spine fusion and large segmental defects are the toughest bone healing applications.  SkelRegen has the only proven osteoinductive small molecules that can make bone from scratch demonstrated in pre-clinical studies.

 Skeletal Trauma

Trauma, including long bone and vertebral body fractures, is in desperate need of a potent, cost-effective bone grafting alternative.  SkelRegen has several small molecules proven to be osteoinductive, building bone from scratch, which could be formulated and priced specifically for this unique market segment.

 Musculoskeletal Soft Tissue Regeneration

Regenerating ligament, tendon, and cartilage (including joint surface and spinal disc) presents a clinical challenge yet to be solved.  SkelRegen identified several small molecules that activate key pathways in the formation of these soft tissues.

 Scaffolds & Bone Void Fillers

Bone void fillers are typically inert scaffolds that allow passive ingrowth, but are only useful in relatively favorable healing environments.  SkelRegen has small molecules that will dramatically enhance the bone and cartilage forming potential of any scaffold as demonstrated in pre-clinical studies.  These bioactivated scaffolds have been shown to enhance healing when used alone, with bone marrow, or with stem cells.


Most osteoporosis treatments slow bone loss.  SkelRegen has identified a small molecule that could result in increased bone formation.  It’s not slowing bone loss; it’s increasing bone formation.  It seems like a better approach.